Mezini holds a LOEWE top professorship for computer science at TU Darmstadt and heads the Software Technology Group in the Department of Computer Science. She is also the founding co-director of hessian.AI, the Hessian Centre for Artificial Intelligence, and a member of the board of the National Research Centre for Applied Cybersecurity ATHENE.

Mezini conducts research in the fields of programming languages and software engineering. She was one of the pioneers of machine learning techniques for the automatic completion of programmes.

As part of her LOEWE top professorship, she focuses on research into programming principles for the development of reliable and trustworthy decentralised interactive-learning software systems.Mezini's research has been recognised with several awards.

In particular, she received a highly prestigious Advanced Grant from the European Research Council in 2012. She has been a member of the German Academy of Science and Engineering (acatech) since 2016 and a member of Academia Europea since 2024. Mira Mezini was named an ACM Fellow in 2024 – one of the most prestigious honours in computer science worldwide. The appointment as an ACM Fellow underlines Mezini's outstanding international reputation and confirms her position among the global elite of computer science research.

Founded in 1652, the Leopoldina is the oldest academy of sciences in the world. In 2008, it was declared the National Academy of Sciences of Germany. The Leopoldina advises politicians and the public on scientific issues, sets up commissions and represents German science in international bodies.

Its members are scientists who have made a significant contribution to science and society through their outstanding research achievements. Past members of the Academy include Johann Wolfgang von Goethe, Alexander von Humboldt, Charles Darwin, Marie Curie and Werner Heisenberg. Other members include Prof Dr Iryna Gurevych and Prof Dr Johannes A. Buchmann (retired).